keratoconus

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	140
interventional	90
Observational	48
Registry	2

Studies over Time by Start Date

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Interventional Trials

Intervention Type

intervention_type	Study_Count
Procedure	34
Device	16
Drug	13
Combination Product	6
Device|Drug	4
Drug|Procedure	4
Device|Drug|placebo	3
Device|Procedure	3
Other	2
Behavioral	1
Device|Drug|Procedure	1
Device|placebo	1
Dietary Supplement	1
Radiation	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	29
NA	13
Brazil	7
Iran, Islamic Republic of	6
United Kingdom	5
France	4
Austria	3
Egypt	3
Italy	3
Canada	2
Netherlands	2
Sweden	2
Bulgaria|France|Spain|Turkey	1
Germany	1
Greece	1
India	1
Israel	1
Mexico	1
Norway	1
Saudi Arabia	1
Switzerland	1
Turkey	1
United States|Switzerland	1

Sites per Study

Site_count	Study_Count
1	82
2	2
3	1
4	1
8	1
10	2
14	1

Phase

Phase	Study_Count
N/A	53
Phase 3	11
Phase 2/Phase 3	8
Phase 2	7
Phase 4	6
Phase 1	4
Phase 1/Phase 2	1

Number of Arms

Number_of_Arms	Count_of_Studies
1	29
2	54
3	3
4	1
5	1
NA	2

Enrollment Metrics by Phase

Measure	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	8.00	28	300	14.0000	8.000	3.0000	18.00
1st Qu.	23.75	157	300	20.0000	27.250	50.0000	20.00
Median	35.00	250	300	20.0000	41.000	160.0000	22.50
Mean	81.75	382	300	129.4286	176.125	136.8182	35.50
3rd Qu.	68.75	475	300	161.0000	247.500	195.0000	36.25
Max.	1200.00	1000	300	510.0000	600.000	279.0000	90.00

Trial Group Type

group_type	Group_Count
Active Comparator	73
Experimental	61
Other	10
Placebo Comparator	5
Sham Comparator	5
NA	2
No Intervention	1

Intervention Model

intervention_model	Study_Count
Parallel Assignment	46
Single Group Assignment	36
Crossover Assignment	3
Sequential Assignment	3
Factorial Assignment	1
NA	1

Primary Purpose

primary_purpose	Study_Count
Treatment	75
Other	3
NA	3
Basic Science	2
Diagnostic	2
Supportive Care	2
Health Services Research	1
Prevention	1
Screening	1

Observational Studies

Studies by Country

Country	Study_Count
NA	9
United States	9
France	6
Greece	5
Germany	4
Egypt	3
Austria	2
United Kingdom	2
Brazil	1
China	1
Korea, Republic of	1
Norway	1
Singapore	1
Turkey	1
United States|China|Saudi Arabia	1
United States|United Kingdom	1

Sites per Study

Site_count	Study_Count
1	44
2	2
3	1
8	1

Enrollment Metrics

Measure	Observational
Min	7.0000
1st Qu	36.0000
Median	100.0000
Mean	345.5957
3rd Qu	200.0000
Max	7500.0000

Observation Model

observational_model	Study_Count
Cohort	17
Case-Control	8
Case-Only	8
Case Control	7
Other	5
Case-Crossover	1
Case Control, Natural History	1
Family-Based	1

Time Perspective

time_perspective	Study_Count
Prospective	26
Retrospective	13
Cross-Sectional	7
Cross-Sectional, Prospective	1
Other	1

Registries

Studies by Country

Country	Study_Count
France	1
Germany	1

Sites per Study

Site_count	Study_Count
1	2

Enrollment Metrics

Measure	Registries
Min	564
1st Qu	723
Median	882
Mean	882
3rd Qu	1041
Max	1200

Registry Model

observational_model	Study_Count
Cohort	2

Time Perspective

time_perspective	Study_Count
Other	1
Prospective	1

Follow-up

target_duration	Study_Count
10 Years	1
5 Years	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT04457063	Endothelial Cell Loss After Penetrating Keratoplasty	https://ClinicalTrials.gov/show/NCT04457063	Completed	Alexandria University	2020-06-01
NCT04430244	Deep Anterior Lamellar Keratoplasty Using Dehydrated Versus Standard Organ Culture Stored Donor Corneas	https://ClinicalTrials.gov/show/NCT04430244	Recruiting	Istituto Internazionale di Ricerca e Formazione in Oftalmologia	2023-05-31
NCT02008175	Conventional Collagen Crosslinking in Young Keratoconus	https://ClinicalTrials.gov/show/NCT02008175	Completed	Vasan Eye Care Hospital	2013-06-30
NCT03249233	Corneal Thickness Changes With Scleral Contact Lenses	https://ClinicalTrials.gov/show/NCT03249233	Recruiting	University of Waterloo	2020-12-31
NCT03245853	Epi-On Corneal Crosslinking for Keratoconus	https://ClinicalTrials.gov/show/NCT03245853	Completed	Comprehensive EyeCare of Central Ohio	2019-09-01
NCT03220529	A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea	https://ClinicalTrials.gov/show/NCT03220529	Recruiting	Massachusetts General Hospital	2020-09-30
NCT03127163	Intraestromal Corneal Ring in Mild Keratoconus	https://ClinicalTrials.gov/show/NCT03127163	Completed	University of Sao Paulo	2016-01-10
NCT03095235	Dietary Riboflavin (Vitamin B-2) and Cornea Cross-Linking	https://ClinicalTrials.gov/show/NCT03095235	Recruiting	University of Missouri-Columbia	2022-01-31
NCT03071302	Evaluation of Tomographic and Genetic Aspects of Keratoconus Patients Compared to Sounds Corneas	https://ClinicalTrials.gov/show/NCT03071302	Completed	Sao Jose do Rio Preto Medical School	2016-12-31
NCT02979054	Performance and Safety Assessment of T4020 in Managing Corneal Epithelial Defect Following Epi-off Accelerated Crosslinking	https://ClinicalTrials.gov/show/NCT02979054	Completed	Laboratoires Thea	2018-03-31
NCT02921009	McNeel Eye Center Corneal Crosslinking Study	https://ClinicalTrials.gov/show/NCT02921009	Recruiting	McNeel Eye Center	2020-12-31
NCT02867176	Pain Management in Corneal Collagen Crosslinking for Keratoconus	https://ClinicalTrials.gov/show/NCT02867176	Completed	Instituto de Oftalmología Fundación Conde de Valenciana	2016-07-31
NCT02861339	Prevalence of Keratoconus in Inflammatory Bowel Diseases	https://ClinicalTrials.gov/show/NCT02861339	Completed	Central Hospital, Nancy, France	2014-07-31
NCT02834260	Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : Tolerance and Safety Pilot Study	https://ClinicalTrials.gov/show/NCT02834260	Completed	Centre Hospitalier Universitaire de Saint Etienne	2018-08-28
NCT02806921	Changes in the Tear Film With Scleral Contact Lens Wear for Keratoconic Eyes	https://ClinicalTrials.gov/show/NCT02806921	Completed	University of Waterloo	2018-01-30
NCT02649738	Corneal Tissue Inlay for Keratoconus	https://ClinicalTrials.gov/show/NCT02649738	Recruiting	Cornea and Laser Eye Institute	2021-12-31
NCT02625467	Treatment of Keratoconus With PALK Versus PK	https://ClinicalTrials.gov/show/NCT02625467	Completed	Instituto de Oftalmología Fundación Conde de Valenciana	2014-06-30
NCT02590549	MyoRing Implantation With Corneal Collagen Crosslinking for Keratoconus	https://ClinicalTrials.gov/show/NCT02590549	Completed	Ufa Eye Research Institute	2014-12-31
NCT03890718	Stromal Enhancement in Keratoconus, Using Stromal Lenticules of Myopic SMILE Patients (Simultaneously)	https://ClinicalTrials.gov/show/NCT03890718	Enrolling by invitation	Shahid Beheshti University	2020-09-30
NCT02485951	Central Versus Peripheral Air Injection for DALK (Deep Anterior Lamellar Keratoplasty)	https://ClinicalTrials.gov/show/NCT02485951	Completed	Shahid Beheshti University of Medical Sciences	2015-06-30
NCT02444923	Scleral Versus Corneal RGP Contact Lenses in Irregular Cornea Disorders	https://ClinicalTrials.gov/show/NCT02444923	Completed	London South Bank University	2019-01-29
NCT02349165	Standard Versus Transepithelial Corneal Crosslinking	https://ClinicalTrials.gov/show/NCT02349165	Completed	UMC Utrecht	2014-09-30
NCT02301598	Femtosecond Laser-assisted Anterior Lamellar Keratoplasty	https://ClinicalTrials.gov/show/NCT02301598	Completed	The S.N. Fyodorov Eye Microsurgery State Institution	2012-09-30
NCT02208089	Simultaneous TransPRK and Corneal Collagen Cross-Linking	https://ClinicalTrials.gov/show/NCT02208089	Completed	Moorfields Eye Hospital NHS Foundation Trust	2016-07-31
NCT02189447	Photorefractive Keratectomy and Corneal Cross-linking in Keratoconus	https://ClinicalTrials.gov/show/NCT02189447	Completed	The Eye Center and The Eye Foundation for Research in Ophthalmology	2013-09-30
NCT02173847	Laser Assisted Procedures in Penetrating Keratoplasty	https://ClinicalTrials.gov/show/NCT02173847	Completed	Ospedale Santo Stefano	2013-01-31
NCT02138669	Intacs for Keratoconus	https://ClinicalTrials.gov/show/NCT02138669	Recruiting	University of Texas Southwestern Medical Center	2020-12-31
NCT02119039	Effect of CACICOL20 on Corneal Epithelial Healing After Cross-linking in Patients With Keratoconus	https://ClinicalTrials.gov/show/NCT02119039	Completed	Medical University of Vienna	2015-10-31
NCT02117999	Transepithelial Corneal Cross-linking Using Iontophoresis	https://ClinicalTrials.gov/show/NCT02117999	Completed	Fondazione G.B. Bietti, IRCCS	2016-06-30
NCT01845714	Impact of Keratoconus, Cross-linking and Cross-linking Combined With Topo-guided Photorefractive Keratectomy on Self-reported Quality of Life. A Three-year Update.	https://ClinicalTrials.gov/show/NCT01845714	Completed	Democritus University of Thrace	2011-04-30
NCT01843101	Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study	https://ClinicalTrials.gov/show/NCT01843101	Recruiting	Medical University of Vienna	2020-01-31
NCT01809977	Comparison of Partial Removal and Total Removal of the Corneal Epithelium on Keratoconus	https://ClinicalTrials.gov/show/NCT01809977	Completed	Isfahan University of Medical Sciences	2012-12-31
NCT01789333	Higher Irradiance in Keratoconus Ectasia	https://ClinicalTrials.gov/show/NCT01789333	Recruiting	Columbia University	2019-12-31
NCT01743443	Corneal Sensitivity Cross-linking Keratoconus	https://ClinicalTrials.gov/show/NCT01743443	Completed	Instituto de Olhos de Goiania	2012-10-31
NCT01708538	The Effects of Corneal Collagen Cross-linking	https://ClinicalTrials.gov/show/NCT01708538	Recruiting	Rush Eye Associates	2020-10-31
NCT01691651	Botulinum Toxin A for the Treatment of Keratoconus	https://ClinicalTrials.gov/show/NCT01691651	Completed	Federal University of São Paulo	2014-10-31
NCT01686906	Isolated Bowman Layer Graft for Reducing and Stabilizing Advanced Keratoconus	https://ClinicalTrials.gov/show/NCT01686906	Recruiting	Netherlands Institute for Innovative Ocular Surgery	2020-12-31
NCT01672814	Microwave Treatment and Corneal Collagen Crosslinking for Keratoconus	https://ClinicalTrials.gov/show/NCT01672814	Completed	Cornea and Laser Eye Institute	2017-06-01
NCT01643226	Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus	https://ClinicalTrials.gov/show/NCT01643226	Completed	Avedro, Inc.	2015-07-31
NCT01527721	Blurring Strength & Aberrometric Changes Following Corneal Cross-linking (CxL) and CxL Combined With Photorefractive Keratectomy (PRK) in Keratoconus	https://ClinicalTrials.gov/show/NCT01527721	Completed	Democritus University of Thrace	2011-12-31
NCT01485211	Corneal Thickness Changes During Corneal Collagen Cross-linking With Ultraviolet-A Irradiation and Riboflavin	https://ClinicalTrials.gov/show/NCT01485211	Completed	Instituto de Olhos de Goiania	2011-11-30
NCT01464268	Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia	https://ClinicalTrials.gov/show/NCT01464268	Active, not recruiting	Cornea and Laser Eye Institute	2021-02-28
NCT01344187	Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus	https://ClinicalTrials.gov/show/NCT01344187	Completed	Avedro, Inc.	2015-06-30
NCT04427956	Corneal Crosslinking Treatment Study	https://ClinicalTrials.gov/show/NCT04427956	Recruiting	Region Skane	2021-12-31
NCT04401865	Safety and Effectiveness of the PXL-Platinum 330 System	https://ClinicalTrials.gov/show/NCT04401865	Recruiting	Colorado Eye Consultants/Cornea Consultants of Colorado	2021-12-31
NCT04383301	Combined Corneal Wavefront-guided TPRK and ACXL Following ICRS Implantation in Management of Moderate Keratoconus	https://ClinicalTrials.gov/show/NCT04383301	Completed	Minia University	2020-04-30
NCT04343326	The Additional Role of Supplemental Oxygen Therapy in Accelerated Corneal Collagen Cross-linking in Progressive Keratoconus. A Randomized Clinical Trial	https://ClinicalTrials.gov/show/NCT04343326	Recruiting	Shahid Beheshti University of Medical Sciences	2020-05-01
NCT04213885	Safety and Effectiveness of the PXL Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Position	https://ClinicalTrials.gov/show/NCT04213885	Recruiting	Eye Specialists of Indiana	2029-09-01
NCT04177082	Safety and Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution	https://ClinicalTrials.gov/show/NCT04177082	Recruiting	Cornea Associates of Texas	2029-08-31
NCT04174209	CHOICE OF SUBJECTIVE OCULAR REFRACTION TECHNIQUE AND CORNEAL TOPOGRAPHY OF KERATOCONUS	https://ClinicalTrials.gov/show/NCT04174209	Completed	University Hospital, Clermont-Ferrand	2020-03-06
NCT04168112	Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study	https://ClinicalTrials.gov/show/NCT04168112	Recruiting	Sight Medical Doctors PLLC	2020-11-30
NCT04130334	Effects of Corneal Anatomical Match Between Donor and Recipient During DALK Surgery on Final Visual and Refractive Outcomes in Patients With KCN	https://ClinicalTrials.gov/show/NCT04130334	Recruiting	Shahid Beheshti University of Medical Sciences	2019-06-01
NCT04129021	Multimodal Ophthalmic Imaging	https://ClinicalTrials.gov/show/NCT04129021	Recruiting	Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts	2023-06-30
NCT04094090	Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia	https://ClinicalTrials.gov/show/NCT04094090	Recruiting	Goodman Eye Center	2029-08-31
NCT04062435	Corneal Uptake of Riboflavin Eye Drops	https://ClinicalTrials.gov/show/NCT04062435	Completed	Luzerner Kantonsspital	2020-03-01
NCT04045626	Study of Demarcation Line Depth in Transepithelial Versus Epithelium-off Accelerated Cross-linking (AXL) in Keratocouns	https://ClinicalTrials.gov/show/NCT04045626	Recruiting	Kasr El Aini Hospital	2020-01-31
NCT03990506	Photorefractive Intrastromal Crosslinking (PiXL) for the Treatment of Progressive Keratoconus	https://ClinicalTrials.gov/show/NCT03990506	Recruiting	Umeå University	2021-06-02
NCT03922542	Comparison of Standard vs. Accelerated Corneal Crosslinking	https://ClinicalTrials.gov/show/NCT03922542	Recruiting	Price Vision Group	2025-04-01
NCT03918408	Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Conditions	https://ClinicalTrials.gov/show/NCT03918408	Recruiting	Pacific Clear Vision Institute	2029-06-30
NCT03879421	Evaluation of the Keratoconic Cornea After Corneal Collagen Cross Linking.	https://ClinicalTrials.gov/show/NCT03879421	Recruiting	Assiut University	2019-04-30
NCT03760770	Riboflavin at 4ºC for the Management of Pain After Crosslinking for Keratoconus Patients	https://ClinicalTrials.gov/show/NCT03760770	Recruiting	Instituto de Oftalmología Fundación Conde de Valenciana	2019-02-01
NCT03760432	Collagen Cross-linking in Keratoconus	https://ClinicalTrials.gov/show/NCT03760432	Recruiting	Oregon Health and Science University	2023-12-31
NCT03732599	Comparison Between Standard Deep Anterior Lamellar Keratoplasty (S-DALK) and Intralase Enabled Deep Anterior Lamellar Keratoplaty (IE-DALK)	https://ClinicalTrials.gov/show/NCT03732599	Enrolling by invitation	University of Toronto	2019-12-31
NCT03647046	Custom Anterior Surfacing of Scleral Lens for Vision Quality Improvement in Patients With Keratoconus	https://ClinicalTrials.gov/show/NCT03647046	Completed	University of Rochester	2020-01-20
NCT03619434	Femtolaser Assisted Keratoplasty Versus Conventional Keratoplasty	https://ClinicalTrials.gov/show/NCT03619434	Recruiting	University of Southampton	2020-12-26
NCT03598634	Epi Off Versus Epi on Corneal Collagen Cross-linking in Keratoconus Patients	https://ClinicalTrials.gov/show/NCT03598634	Completed	University of Molise	2015-06-30
NCT03584243	Transepithelial Corneal Collagen Crosslinking in Eyes With Progressive Keratoconus	https://ClinicalTrials.gov/show/NCT03584243	Active, not recruiting	University Hospital, Toulouse	2018-09-30
NCT03560609	Optic Nerve Head Structural Response to IOP Elevation in Patients With Keratoconus	https://ClinicalTrials.gov/show/NCT03560609	Recruiting	NYU Langone Health	2021-12-31
NCT03531047	Refractive Corneal Cross-linking for Progressive Keratoconus	https://ClinicalTrials.gov/show/NCT03531047	Recruiting	Moorfields Eye Hospital NHS Foundation Trust	2021-11-30
NCT03442751	Study to Evaluate the Safety and Efficacy of Epi-on Corneal Cross-linking in Eyes With Progressive Keratoconus	https://ClinicalTrials.gov/show/NCT03442751	Active, not recruiting	Avedro, Inc.	2019-11-01
NCT01181219	Transepithelial Corneal Collagen Cross-linking (CXL) in Treatment of Keratoconus	https://ClinicalTrials.gov/show/NCT01181219	Completed	University Hospital of North Norway	2014-12-31
NCT01152541	Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin	https://ClinicalTrials.gov/show/NCT01152541	Active, not recruiting	Cornea and Laser Eye Institute	2021-12-31
NCT01143389	Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia	https://ClinicalTrials.gov/show/NCT01143389	Completed	Price Vision Group	2017-05-30
NCT01112072	Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia	https://ClinicalTrials.gov/show/NCT01112072	Active, not recruiting	Cornea and Laser Eye Institute	2021-12-31
NCT01081561	Collagen Cross-Linking for Keratoconus/Ectasia With and Without Intacs	https://ClinicalTrials.gov/show/NCT01081561	Enrolling by invitation	Cornea Genetic Eye Institute	2020-12-30
NCT01069848	Feasibility Study of the Vedera KXS for Treatment of Keratoconus	https://ClinicalTrials.gov/show/NCT01069848	Completed	Avedro, Inc.	2011-03-31
NCT00887900	Deep Anterior Lamellar Keratoplasty (DALK)	https://ClinicalTrials.gov/show/NCT00887900	Completed	Hospital Oftalmologico de Brasilia	2007-12-31
NCT00850148	Comparison of Anwar and Melles Techniques in Deep Anterior Lamellar Keratoplasty (DALK) for Keratoconus Patients	https://ClinicalTrials.gov/show/NCT00850148	Completed	Shahid Beheshti University of Medical Sciences	2009-06-30
NCT00832897	Evaluation of Topical Riboflavin Exposed to UVA Radiation and Implantation of Corneal Ring	https://ClinicalTrials.gov/show/NCT00832897	Completed	Federal University of São Paulo	2008-11-30
NCT03091101	Impact of Scleral Contact Lens Wear on Corneal Nerves in Keratoconus	https://ClinicalTrials.gov/show/NCT03091101	Completed	University of Waterloo	2018-03-21
NCT01411384	Evaluation of Corneal Hysteresis and Corneal Resistance Factor After Corneal Cross-linking for Keratoconus	https://ClinicalTrials.gov/show/NCT01411384	Completed	Democritus University of Thrace	2009-04-30
NCT00802776	Femtosecond Laser Assisted Keratoplasty	https://ClinicalTrials.gov/show/NCT00802776	Completed	University of Michigan	2010-12-31
NCT03187912	Accelerated Corneal Cross-linking With Different Riboflavin Solutions	https://ClinicalTrials.gov/show/NCT03187912	Active, not recruiting	Medical University of Vienna	2019-06-30
NCT02456961	Standard Corneal Collagen Crosslinking Versus Transepithelial Corneal Crosslinking by Iontophoresis of Riboflavin	https://ClinicalTrials.gov/show/NCT02456961	Completed	Ufa Eye Research Institute	2014-12-31
NCT00777322	T-Cat Laser & Cross-linking for Keratoconus	https://ClinicalTrials.gov/show/NCT00777322	Completed	Moorfields Eye Hospital NHS Foundation Trust	2010-10-31
NCT00647699	Corneal Collagen Cross-linking for Progressive Keratoconus	https://ClinicalTrials.gov/show/NCT00647699	Completed	Avedro, Inc.	2011-04-30
NCT00626717	Riboflavin Mediated Corneal Crosslinking for Stabilizing Progression of Keratoconus	https://ClinicalTrials.gov/show/NCT00626717	Completed	University Hospital Freiburg	2012-12-31
NCT00593190	Intracameral Gas SF6 (Sulfur Hexafluoride) Injection for Acute Hydrops in Keratoconus	https://ClinicalTrials.gov/show/NCT00593190	Completed	HaEmek Medical Center, Israel	2008-12-31
NCT00567671	Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia	https://ClinicalTrials.gov/show/NCT00567671	Completed	Emory University	2010-06-30
NCT00409955	Lamellar Transplant With Lyophilized Corneas	https://ClinicalTrials.gov/show/NCT00409955	Completed	Federal University of São Paulo	NA

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03115710	The K-Map Study, Global Prevalence of KC	https://ClinicalTrials.gov/show/NCT03115710	Recruiting	University Hospital, Geneva	2021-02-01
NCT03030755	Corneal Elastography and Patient Specific Modeling	https://ClinicalTrials.gov/show/NCT03030755	Recruiting	The Cleveland Clinic	2020-05-31
NCT02891655	KERatoconus and Metalloproteinases InvesTigation	https://ClinicalTrials.gov/show/NCT02891655	Recruiting	Fondation Ophtalmologique Adolphe de Rothschild	2020-06-30
NCT02883881	Correlation Between Eye Rubbing and Keratoconus Severity in a Treatment-naive Keratoconic Population	https://ClinicalTrials.gov/show/NCT02883881	Completed	Centre Hospitalier Régional Metz-Thionville	2015-12-31
NCT02883868	Stromal Demarcation Line: is it Predictive for Cross-Linking Efficiency?	https://ClinicalTrials.gov/show/NCT02883868	Completed	Centre Hospitalier Régional Metz-Thionville	2015-12-31
NCT02875145	Impact of Cataract Surgery on Keratoplasty Graft Survival	https://ClinicalTrials.gov/show/NCT02875145	Completed	Centre Hospitalier Universitaire de Besancon	2015-08-31
NCT02812563	Familial Analysis of Keratoconus Risk	https://ClinicalTrials.gov/show/NCT02812563	Completed	University Hospital, Bordeaux	2017-09-19
NCT02698709	Astigmatic Vector Analysis of Posterior Cornea - a Comparison Among Healthy, Forme Fruste and Overt Keratoconus Corneas	https://ClinicalTrials.gov/show/NCT02698709	Completed	University of Sao Paulo	2015-08-31
NCT02617368	Fourier Transform of Videokeratography Data: Clinical Usefulness in Moderate and Frome Fruste Keratoconus	https://ClinicalTrials.gov/show/NCT02617368	Completed	Democritus University of Thrace	2015-11-30
NCT02476149	Biomechanical Properties of Keratoconic Eyes	https://ClinicalTrials.gov/show/NCT02476149	Recruiting	University of Plymouth	2019-12-31
NCT02428166	Corneal Changes After Crosslinking in Keratoconus Patients Compared to the Untreated Fellow Eye	https://ClinicalTrials.gov/show/NCT02428166	Completed	Heidelberg University	2017-03-31
NCT02118922	A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia	https://ClinicalTrials.gov/show/NCT02118922	Recruiting	Massachusetts General Hospital	2020-09-30
NCT02109848	Observational Study of Keratoconus and Post-keratoplasty Eyes	https://ClinicalTrials.gov/show/NCT02109848	Completed	Oregon Health and Science University	2017-08-31
NCT03355430	Simultaneous Corneal Wavefront-Guided Trans-PRK and Corneal Collagen Crosslinking After ICRS Implantation for Moderate Keratoconus	https://ClinicalTrials.gov/show/NCT03355430	Completed	Yonsei University	2017-01-02
NCT01879631	Efficacy of Radial Keratotomy in the Optical Rehabilitation of Mild to Moderate Keratoconus Cases	https://ClinicalTrials.gov/show/NCT01879631	Completed	Nisa Hastanesi	2012-11-30
NCT01726283	Combined CXL//UV and PRK or LASIK in Forme Fruste Keratoconus or Eyes With Potential Risk of Ectasia	https://ClinicalTrials.gov/show/NCT01726283	Completed	Cxlusa	2014-07-31
NCT01695811	Femtosecond Laser-Assisted Keratoplasty	https://ClinicalTrials.gov/show/NCT01695811	Completed	University of Michigan	2012-03-31
NCT01654614	Diagnostic Capacity of Keratoconus Match Index and Keratoconus Match Probability in Forme Fruste Keratoconus	https://ClinicalTrials.gov/show/NCT01654614	Completed	Democritus University of Thrace	2012-06-30
NCT01527708	Accuracy of Curvature and Wavefront Aberrations of Posterior Corneal Surface, in Keratoconic and Post-CXL Corneas	https://ClinicalTrials.gov/show/NCT01527708	Completed	Democritus University of Thrace	2011-11-30
NCT01510392	CEI Van Outreach Screening Study	https://ClinicalTrials.gov/show/NCT01510392	Completed	Oregon Health and Science University	2017-02-02
NCT01448408	Corneal Biomechanical Properties and Anterior Segment Parameters, in Forme Fruste Keratoconus	https://ClinicalTrials.gov/show/NCT01448408	Completed	Democritus University of Thrace	NA
NCT01403129	Keratoconus Detection by Ultrasound	https://ClinicalTrials.gov/show/NCT01403129	Enrolling by invitation	Columbia University	2019-09-30
NCT04433936	Corneal Tomographic Parameters in TGD	https://ClinicalTrials.gov/show/NCT04433936	Completed	Mansoura University	2018-06-01
NCT04422080	Retrospective Observational Study of Posterior Keratometry Measured	https://ClinicalTrials.gov/show/NCT04422080	Completed	University Hospital, Montpellier	2020-06-01
NCT04383366	Agreement and Accuracy of Different Devices Corneal Measurements	https://ClinicalTrials.gov/show/NCT04383366	Recruiting	Medical University of Vienna	2020-10-21
NCT04346992	Prevalence Of Keratoconus Among Patients With Thyroid Gland Dysfunction	https://ClinicalTrials.gov/show/NCT04346992	Recruiting	Fayoum University	2020-08-31
NCT04313387	Efficiency of an Algorithm Derived From Corneal Tomography Parameters to Distinguish Highly Susceptible Corneas to Ectasia From Healthy	https://ClinicalTrials.gov/show/NCT04313387	Completed	Sao Jose do Rio Preto Medical School	2018-01-01
NCT04251143	Dresden Corneal Disease and Treatment Study	https://ClinicalTrials.gov/show/NCT04251143	Recruiting	Technische Universität Dresden	2025-12-31
NCT04249180	Eye Rubbing and Keratoconus in Montpellier CHU	https://ClinicalTrials.gov/show/NCT04249180	Recruiting	University Hospital, Montpellier	2020-06-01
NCT04180111	Cross Linking Corneal Biomechanical Evaluation of CATS Tonometer Prism	https://ClinicalTrials.gov/show/NCT04180111	Recruiting	Intuor Technologies, Inc.	2019-12-30
NCT04164407	Keratoconus, Corneal Diseases and Transplant Registry	https://ClinicalTrials.gov/show/NCT04164407	Recruiting	University Hospital, Montpellier	2021-12-01
NCT03753009	Iontophoretic Transepithelial Collagen Cross-linking Versus Epithelium-off Collagen Cross-linking in Pediatric Patients. Three Year Follow up.	https://ClinicalTrials.gov/show/NCT03753009	Completed	Bambino Gesù Hospital and Research Institute	2015-06-30
NCT03661164	Iontophoretic Transepithelial Corneal Cross-linking in Pediatric Patients	https://ClinicalTrials.gov/show/NCT03661164	Completed	Bambino Gesù Hospital and Research Institute	2015-06-30
NCT03637673	The Possible Role of Thyroxine in Keratoconus Development	https://ClinicalTrials.gov/show/NCT03637673	Recruiting	Alexandria University	2018-08-30
NCT03511495	Reliability of Topography Measurements in Keratoconus	https://ClinicalTrials.gov/show/NCT03511495	Completed	Milton S. Hershey Medical Center	2019-03-31
NCT03504800	OCT in Diagnosis of Irregular Corneas	https://ClinicalTrials.gov/show/NCT03504800	Recruiting	Oregon Health and Science University	2023-04-30
NCT03462355	Tobacco Smoking Among Crosslinked-keratoconus Patients	https://ClinicalTrials.gov/show/NCT03462355	Completed	Centre Hospitalier Régional Metz-Thionville	2017-09-30
NCT01261013	Intrastromal Corneal Ring Segment Implantation in 219 Keratoconic Eyes at Different Stages	https://ClinicalTrials.gov/show/NCT01261013	Completed	Fernandez-Vega Ophthalmological Institute	NA
NCT00863876	Comparison of WaveLight Analyzer and Alcon LadarWave	https://ClinicalTrials.gov/show/NCT00863876	Completed	WaveLight AG	NA
NCT03288116	Objective and Subjective Diagnostic Parameters in the Fellow Eye of Unilateral Keratoconus	https://ClinicalTrials.gov/show/NCT03288116	Completed	Dar Al Shifa Hospital	2015-02-05
NCT01471873	Variability of Pentacam-derived Back Elevation Measurements in Keratoconus and Cross-linked Corneas	https://ClinicalTrials.gov/show/NCT01471873	Completed	Democritus University of Thrace	2011-09-30
NCT03184610	Distinguishing Healthy and Keratoconic Eyes Using Ultrahigh-Resolution OCT	https://ClinicalTrials.gov/show/NCT03184610	Completed	Medical University of Vienna	2017-06-30
NCT02023619	Corneal Epithelial and Stromal Thickness Distribution in Keratoconus	https://ClinicalTrials.gov/show/NCT02023619	Completed	SynsLaser Kirurgi AS	2013-09-30
NCT04299399	Corneal Biomechanical Changes of Allergic Conjunctivitis	https://ClinicalTrials.gov/show/NCT04299399	Recruiting	Zhongshan Ophthalmic Center, Sun Yat-sen University	2021-05-31
NCT00584285	Corneal Topographer Fluorescein Patterns	https://ClinicalTrials.gov/show/NCT00584285	Completed	University of Iowa	2009-09-04
NCT00560651	German Corneal Cross Linking Register	https://ClinicalTrials.gov/show/NCT00560651	Recruiting	St. Franziskus Hospital	2027-11-30
NCT00347191	Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments.	https://ClinicalTrials.gov/show/NCT00347191	Completed	Aston University	NA
NCT00347074	A Clinical Study of Keratoconus in Asian Patients and Assessment of Different Topographic Patterns of Keratoconus in Asian Patients	https://ClinicalTrials.gov/show/NCT00347074	Completed	Singapore National Eye Centre	NA

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT02849808	Long Term Cornea Graft Survival Study	https://ClinicalTrials.gov/show/NCT02849808	Completed	Centre Hospitalier Universitaire de Besancon	2017-08-03
NCT03923101	The Homburg Keratoconus Center (HKC)	https://ClinicalTrials.gov/show/NCT03923101	Recruiting	Saarland University	2021-01-01