Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 140
interventional 90
Observational 48
Registry 2

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Procedure 34
Device 16
Drug 13
Combination Product 6
Device|Drug 4
Drug|Procedure 4
Device|Drug|placebo 3
Device|Procedure 3
Other 2
Behavioral 1
Device|Drug|Procedure 1
Device|placebo 1
Dietary Supplement 1
Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 29
NA 13
Brazil 7
Iran, Islamic Republic of 6
United Kingdom 5
France 4
Austria 3
Egypt 3
Italy 3
Canada 2
Netherlands 2
Sweden 2
Bulgaria|France|Spain|Turkey 1
Germany 1
Greece 1
India 1
Israel 1
Mexico 1
Norway 1
Saudi Arabia 1
Switzerland 1
Turkey 1
United States|Switzerland 1

Sites per Study

Site_count Study_Count
1 82
2 2
3 1
4 1
8 1
10 2
14 1

Phase

Phase Study_Count
N/A 53
Phase 3 11
Phase 2/Phase 3 8
Phase 2 7
Phase 4 6
Phase 1 4
Phase 1/Phase 2 1

Number of Arms

Number_of_Arms Count_of_Studies
1 29
2 54
3 3
4 1
5 1
NA 2

Enrollment Metrics by Phase

Measure N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 8.00 28 300 14.0000 8.000 3.0000 18.00
1st Qu. 23.75 157 300 20.0000 27.250 50.0000 20.00
Median 35.00 250 300 20.0000 41.000 160.0000 22.50
Mean 81.75 382 300 129.4286 176.125 136.8182 35.50
3rd Qu. 68.75 475 300 161.0000 247.500 195.0000 36.25
Max. 1200.00 1000 300 510.0000 600.000 279.0000 90.00

Trial Group Type

group_type Group_Count
Active Comparator 73
Experimental 61
Other 10
Placebo Comparator 5
Sham Comparator 5
NA 2
No Intervention 1

Intervention Model

intervention_model Study_Count
Parallel Assignment 46
Single Group Assignment 36
Crossover Assignment 3
Sequential Assignment 3
Factorial Assignment 1
NA 1

Primary Purpose

primary_purpose Study_Count
Treatment 75
Other 3
NA 3
Basic Science 2
Diagnostic 2
Supportive Care 2
Health Services Research 1
Prevention 1
Screening 1

Observational Studies

Studies by Country

Country Study_Count
NA 9
United States 9
France 6
Greece 5
Germany 4
Egypt 3
Austria 2
United Kingdom 2
Brazil 1
China 1
Korea, Republic of 1
Norway 1
Singapore 1
Turkey 1
United States|China|Saudi Arabia 1
United States|United Kingdom 1

Sites per Study

Site_count Study_Count
1 44
2 2
3 1
8 1

Enrollment Metrics

Measure Observational
Min 7.0000
1st Qu 36.0000
Median 100.0000
Mean 345.5957
3rd Qu 200.0000
Max 7500.0000

Observation Model

observational_model Study_Count
Cohort 17
Case-Control 8
Case-Only 8
Case Control 7
Other 5
Case-Crossover 1
Case Control, Natural History 1
Family-Based 1

Time Perspective

time_perspective Study_Count
Prospective 26
Retrospective 13
Cross-Sectional 7
Cross-Sectional, Prospective 1
Other 1

Registries

Studies by Country

Country Study_Count
France 1
Germany 1

Sites per Study

Site_count Study_Count
1 2

Enrollment Metrics

Measure Registries
Min 564
1st Qu 723
Median 882
Mean 882
3rd Qu 1041
Max 1200

Registry Model

observational_model Study_Count
Cohort 2

Time Perspective

time_perspective Study_Count
Other 1
Prospective 1

Follow-up

target_duration Study_Count
10 Years 1
5 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04457063 Endothelial Cell Loss After Penetrating Keratoplasty https://ClinicalTrials.gov/show/NCT04457063 Completed Alexandria University 2020-06-01
NCT04430244 Deep Anterior Lamellar Keratoplasty Using Dehydrated Versus Standard Organ Culture Stored Donor Corneas https://ClinicalTrials.gov/show/NCT04430244 Recruiting Istituto Internazionale di Ricerca e Formazione in Oftalmologia 2023-05-31
NCT02008175 Conventional Collagen Crosslinking in Young Keratoconus https://ClinicalTrials.gov/show/NCT02008175 Completed Vasan Eye Care Hospital 2013-06-30
NCT03249233 Corneal Thickness Changes With Scleral Contact Lenses https://ClinicalTrials.gov/show/NCT03249233 Recruiting University of Waterloo 2020-12-31
NCT03245853 Epi-On Corneal Crosslinking for Keratoconus https://ClinicalTrials.gov/show/NCT03245853 Completed Comprehensive EyeCare of Central Ohio 2019-09-01
NCT03220529 A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea https://ClinicalTrials.gov/show/NCT03220529 Recruiting Massachusetts General Hospital 2020-09-30
NCT03127163 Intraestromal Corneal Ring in Mild Keratoconus https://ClinicalTrials.gov/show/NCT03127163 Completed University of Sao Paulo 2016-01-10
NCT03095235 Dietary Riboflavin (Vitamin B-2) and Cornea Cross-Linking https://ClinicalTrials.gov/show/NCT03095235 Recruiting University of Missouri-Columbia 2022-01-31
NCT03071302 Evaluation of Tomographic and Genetic Aspects of Keratoconus Patients Compared to Sounds Corneas https://ClinicalTrials.gov/show/NCT03071302 Completed Sao Jose do Rio Preto Medical School 2016-12-31
NCT02979054 Performance and Safety Assessment of T4020 in Managing Corneal Epithelial Defect Following Epi-off Accelerated Crosslinking https://ClinicalTrials.gov/show/NCT02979054 Completed Laboratoires Thea 2018-03-31
NCT02921009 McNeel Eye Center Corneal Crosslinking Study https://ClinicalTrials.gov/show/NCT02921009 Recruiting McNeel Eye Center 2020-12-31
NCT02867176 Pain Management in Corneal Collagen Crosslinking for Keratoconus https://ClinicalTrials.gov/show/NCT02867176 Completed Instituto de Oftalmología Fundación Conde de Valenciana 2016-07-31
NCT02861339 Prevalence of Keratoconus in Inflammatory Bowel Diseases https://ClinicalTrials.gov/show/NCT02861339 Completed Central Hospital, Nancy, France 2014-07-31
NCT02834260 Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : Tolerance and Safety Pilot Study https://ClinicalTrials.gov/show/NCT02834260 Completed Centre Hospitalier Universitaire de Saint Etienne 2018-08-28
NCT02806921 Changes in the Tear Film With Scleral Contact Lens Wear for Keratoconic Eyes https://ClinicalTrials.gov/show/NCT02806921 Completed University of Waterloo 2018-01-30
NCT02649738 Corneal Tissue Inlay for Keratoconus https://ClinicalTrials.gov/show/NCT02649738 Recruiting Cornea and Laser Eye Institute 2021-12-31
NCT02625467 Treatment of Keratoconus With PALK Versus PK https://ClinicalTrials.gov/show/NCT02625467 Completed Instituto de Oftalmología Fundación Conde de Valenciana 2014-06-30
NCT02590549 MyoRing Implantation With Corneal Collagen Crosslinking for Keratoconus https://ClinicalTrials.gov/show/NCT02590549 Completed Ufa Eye Research Institute 2014-12-31
NCT03890718 Stromal Enhancement in Keratoconus, Using Stromal Lenticules of Myopic SMILE Patients (Simultaneously) https://ClinicalTrials.gov/show/NCT03890718 Enrolling by invitation Shahid Beheshti University 2020-09-30
NCT02485951 Central Versus Peripheral Air Injection for DALK (Deep Anterior Lamellar Keratoplasty) https://ClinicalTrials.gov/show/NCT02485951 Completed Shahid Beheshti University of Medical Sciences 2015-06-30
NCT02444923 Scleral Versus Corneal RGP Contact Lenses in Irregular Cornea Disorders https://ClinicalTrials.gov/show/NCT02444923 Completed London South Bank University 2019-01-29
NCT02349165 Standard Versus Transepithelial Corneal Crosslinking https://ClinicalTrials.gov/show/NCT02349165 Completed UMC Utrecht 2014-09-30
NCT02301598 Femtosecond Laser-assisted Anterior Lamellar Keratoplasty https://ClinicalTrials.gov/show/NCT02301598 Completed The S.N. Fyodorov Eye Microsurgery State Institution 2012-09-30
NCT02208089 Simultaneous TransPRK and Corneal Collagen Cross-Linking https://ClinicalTrials.gov/show/NCT02208089 Completed Moorfields Eye Hospital NHS Foundation Trust 2016-07-31
NCT02189447 Photorefractive Keratectomy and Corneal Cross-linking in Keratoconus https://ClinicalTrials.gov/show/NCT02189447 Completed The Eye Center and The Eye Foundation for Research in Ophthalmology 2013-09-30
NCT02173847 Laser Assisted Procedures in Penetrating Keratoplasty https://ClinicalTrials.gov/show/NCT02173847 Completed Ospedale Santo Stefano 2013-01-31
NCT02138669 Intacs for Keratoconus https://ClinicalTrials.gov/show/NCT02138669 Recruiting University of Texas Southwestern Medical Center 2020-12-31
NCT02119039 Effect of CACICOL20 on Corneal Epithelial Healing After Cross-linking in Patients With Keratoconus https://ClinicalTrials.gov/show/NCT02119039 Completed Medical University of Vienna 2015-10-31
NCT02117999 Transepithelial Corneal Cross-linking Using Iontophoresis https://ClinicalTrials.gov/show/NCT02117999 Completed Fondazione G.B. Bietti, IRCCS 2016-06-30
NCT01845714 Impact of Keratoconus, Cross-linking and Cross-linking Combined With Topo-guided Photorefractive Keratectomy on Self-reported Quality of Life. A Three-year Update. https://ClinicalTrials.gov/show/NCT01845714 Completed Democritus University of Thrace 2011-04-30
NCT01843101 Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study https://ClinicalTrials.gov/show/NCT01843101 Recruiting Medical University of Vienna 2020-01-31
NCT01809977 Comparison of Partial Removal and Total Removal of the Corneal Epithelium on Keratoconus https://ClinicalTrials.gov/show/NCT01809977 Completed Isfahan University of Medical Sciences 2012-12-31
NCT01789333 Higher Irradiance in Keratoconus Ectasia https://ClinicalTrials.gov/show/NCT01789333 Recruiting Columbia University 2019-12-31
NCT01743443 Corneal Sensitivity Cross-linking Keratoconus https://ClinicalTrials.gov/show/NCT01743443 Completed Instituto de Olhos de Goiania 2012-10-31
NCT01708538 The Effects of Corneal Collagen Cross-linking https://ClinicalTrials.gov/show/NCT01708538 Recruiting Rush Eye Associates 2020-10-31
NCT01691651 Botulinum Toxin A for the Treatment of Keratoconus https://ClinicalTrials.gov/show/NCT01691651 Completed Federal University of São Paulo 2014-10-31
NCT01686906 Isolated Bowman Layer Graft for Reducing and Stabilizing Advanced Keratoconus https://ClinicalTrials.gov/show/NCT01686906 Recruiting Netherlands Institute for Innovative Ocular Surgery 2020-12-31
NCT01672814 Microwave Treatment and Corneal Collagen Crosslinking for Keratoconus https://ClinicalTrials.gov/show/NCT01672814 Completed Cornea and Laser Eye Institute 2017-06-01
NCT01643226 Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus https://ClinicalTrials.gov/show/NCT01643226 Completed Avedro, Inc. 2015-07-31
NCT01527721 Blurring Strength & Aberrometric Changes Following Corneal Cross-linking (CxL) and CxL Combined With Photorefractive Keratectomy (PRK) in Keratoconus https://ClinicalTrials.gov/show/NCT01527721 Completed Democritus University of Thrace 2011-12-31
NCT01485211 Corneal Thickness Changes During Corneal Collagen Cross-linking With Ultraviolet-A Irradiation and Riboflavin https://ClinicalTrials.gov/show/NCT01485211 Completed Instituto de Olhos de Goiania 2011-11-30
NCT01464268 Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia https://ClinicalTrials.gov/show/NCT01464268 Active, not recruiting Cornea and Laser Eye Institute 2021-02-28
NCT01344187 Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus https://ClinicalTrials.gov/show/NCT01344187 Completed Avedro, Inc. 2015-06-30
NCT04427956 Corneal Crosslinking Treatment Study https://ClinicalTrials.gov/show/NCT04427956 Recruiting Region Skane 2021-12-31
NCT04401865 Safety and Effectiveness of the PXL-Platinum 330 System https://ClinicalTrials.gov/show/NCT04401865 Recruiting Colorado Eye Consultants/Cornea Consultants of Colorado 2021-12-31
NCT04383301 Combined Corneal Wavefront-guided TPRK and ACXL Following ICRS Implantation in Management of Moderate Keratoconus https://ClinicalTrials.gov/show/NCT04383301 Completed Minia University 2020-04-30
NCT04343326 The Additional Role of Supplemental Oxygen Therapy in Accelerated Corneal Collagen Cross-linking in Progressive Keratoconus. A Randomized Clinical Trial https://ClinicalTrials.gov/show/NCT04343326 Recruiting Shahid Beheshti University of Medical Sciences 2020-05-01
NCT04213885 Safety and Effectiveness of the PXL Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Position https://ClinicalTrials.gov/show/NCT04213885 Recruiting Eye Specialists of Indiana 2029-09-01
NCT04177082 Safety and Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution https://ClinicalTrials.gov/show/NCT04177082 Recruiting Cornea Associates of Texas 2029-08-31
NCT04174209 CHOICE OF SUBJECTIVE OCULAR REFRACTION TECHNIQUE AND CORNEAL TOPOGRAPHY OF KERATOCONUS https://ClinicalTrials.gov/show/NCT04174209 Completed University Hospital, Clermont-Ferrand 2020-03-06
NCT04168112 Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study https://ClinicalTrials.gov/show/NCT04168112 Recruiting Sight Medical Doctors PLLC 2020-11-30
NCT04130334 Effects of Corneal Anatomical Match Between Donor and Recipient During DALK Surgery on Final Visual and Refractive Outcomes in Patients With KCN https://ClinicalTrials.gov/show/NCT04130334 Recruiting Shahid Beheshti University of Medical Sciences 2019-06-01
NCT04129021 Multimodal Ophthalmic Imaging https://ClinicalTrials.gov/show/NCT04129021 Recruiting Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts 2023-06-30
NCT04094090 Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia https://ClinicalTrials.gov/show/NCT04094090 Recruiting Goodman Eye Center 2029-08-31
NCT04062435 Corneal Uptake of Riboflavin Eye Drops https://ClinicalTrials.gov/show/NCT04062435 Completed Luzerner Kantonsspital 2020-03-01
NCT04045626 Study of Demarcation Line Depth in Transepithelial Versus Epithelium-off Accelerated Cross-linking (AXL) in Keratocouns https://ClinicalTrials.gov/show/NCT04045626 Recruiting Kasr El Aini Hospital 2020-01-31
NCT03990506 Photorefractive Intrastromal Crosslinking (PiXL) for the Treatment of Progressive Keratoconus https://ClinicalTrials.gov/show/NCT03990506 Recruiting Umeå University 2021-06-02
NCT03922542 Comparison of Standard vs. Accelerated Corneal Crosslinking https://ClinicalTrials.gov/show/NCT03922542 Recruiting Price Vision Group 2025-04-01
NCT03918408 Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Conditions https://ClinicalTrials.gov/show/NCT03918408 Recruiting Pacific Clear Vision Institute 2029-06-30
NCT03879421 Evaluation of the Keratoconic Cornea After Corneal Collagen Cross Linking. https://ClinicalTrials.gov/show/NCT03879421 Recruiting Assiut University 2019-04-30
NCT03760770 Riboflavin at 4ºC for the Management of Pain After Crosslinking for Keratoconus Patients https://ClinicalTrials.gov/show/NCT03760770 Recruiting Instituto de Oftalmología Fundación Conde de Valenciana 2019-02-01
NCT03760432 Collagen Cross-linking in Keratoconus https://ClinicalTrials.gov/show/NCT03760432 Recruiting Oregon Health and Science University 2023-12-31
NCT03732599 Comparison Between Standard Deep Anterior Lamellar Keratoplasty (S-DALK) and Intralase Enabled Deep Anterior Lamellar Keratoplaty (IE-DALK) https://ClinicalTrials.gov/show/NCT03732599 Enrolling by invitation University of Toronto 2019-12-31
NCT03647046 Custom Anterior Surfacing of Scleral Lens for Vision Quality Improvement in Patients With Keratoconus https://ClinicalTrials.gov/show/NCT03647046 Completed University of Rochester 2020-01-20
NCT03619434 Femtolaser Assisted Keratoplasty Versus Conventional Keratoplasty https://ClinicalTrials.gov/show/NCT03619434 Recruiting University of Southampton 2020-12-26
NCT03598634 Epi Off Versus Epi on Corneal Collagen Cross-linking in Keratoconus Patients https://ClinicalTrials.gov/show/NCT03598634 Completed University of Molise 2015-06-30
NCT03584243 Transepithelial Corneal Collagen Crosslinking in Eyes With Progressive Keratoconus https://ClinicalTrials.gov/show/NCT03584243 Active, not recruiting University Hospital, Toulouse 2018-09-30
NCT03560609 Optic Nerve Head Structural Response to IOP Elevation in Patients With Keratoconus https://ClinicalTrials.gov/show/NCT03560609 Recruiting NYU Langone Health 2021-12-31
NCT03531047 Refractive Corneal Cross-linking for Progressive Keratoconus https://ClinicalTrials.gov/show/NCT03531047 Recruiting Moorfields Eye Hospital NHS Foundation Trust 2021-11-30
NCT03442751 Study to Evaluate the Safety and Efficacy of Epi-on Corneal Cross-linking in Eyes With Progressive Keratoconus https://ClinicalTrials.gov/show/NCT03442751 Active, not recruiting Avedro, Inc. 2019-11-01
NCT01181219 Transepithelial Corneal Collagen Cross-linking (CXL) in Treatment of Keratoconus https://ClinicalTrials.gov/show/NCT01181219 Completed University Hospital of North Norway 2014-12-31
NCT01152541 Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin https://ClinicalTrials.gov/show/NCT01152541 Active, not recruiting Cornea and Laser Eye Institute 2021-12-31
NCT01143389 Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia https://ClinicalTrials.gov/show/NCT01143389 Completed Price Vision Group 2017-05-30
NCT01112072 Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia https://ClinicalTrials.gov/show/NCT01112072 Active, not recruiting Cornea and Laser Eye Institute 2021-12-31
NCT01081561 Collagen Cross-Linking for Keratoconus/Ectasia With and Without Intacs https://ClinicalTrials.gov/show/NCT01081561 Enrolling by invitation Cornea Genetic Eye Institute 2020-12-30
NCT01069848 Feasibility Study of the Vedera KXS for Treatment of Keratoconus https://ClinicalTrials.gov/show/NCT01069848 Completed Avedro, Inc. 2011-03-31
NCT00887900 Deep Anterior Lamellar Keratoplasty (DALK) https://ClinicalTrials.gov/show/NCT00887900 Completed Hospital Oftalmologico de Brasilia 2007-12-31
NCT00850148 Comparison of Anwar and Melles Techniques in Deep Anterior Lamellar Keratoplasty (DALK) for Keratoconus Patients https://ClinicalTrials.gov/show/NCT00850148 Completed Shahid Beheshti University of Medical Sciences 2009-06-30
NCT00832897 Evaluation of Topical Riboflavin Exposed to UVA Radiation and Implantation of Corneal Ring https://ClinicalTrials.gov/show/NCT00832897 Completed Federal University of São Paulo 2008-11-30
NCT03091101 Impact of Scleral Contact Lens Wear on Corneal Nerves in Keratoconus https://ClinicalTrials.gov/show/NCT03091101 Completed University of Waterloo 2018-03-21
NCT01411384 Evaluation of Corneal Hysteresis and Corneal Resistance Factor After Corneal Cross-linking for Keratoconus https://ClinicalTrials.gov/show/NCT01411384 Completed Democritus University of Thrace 2009-04-30
NCT00802776 Femtosecond Laser Assisted Keratoplasty https://ClinicalTrials.gov/show/NCT00802776 Completed University of Michigan 2010-12-31
NCT03187912 Accelerated Corneal Cross-linking With Different Riboflavin Solutions https://ClinicalTrials.gov/show/NCT03187912 Active, not recruiting Medical University of Vienna 2019-06-30
NCT02456961 Standard Corneal Collagen Crosslinking Versus Transepithelial Corneal Crosslinking by Iontophoresis of Riboflavin https://ClinicalTrials.gov/show/NCT02456961 Completed Ufa Eye Research Institute 2014-12-31
NCT00777322 T-Cat Laser & Cross-linking for Keratoconus https://ClinicalTrials.gov/show/NCT00777322 Completed Moorfields Eye Hospital NHS Foundation Trust 2010-10-31
NCT00647699 Corneal Collagen Cross-linking for Progressive Keratoconus https://ClinicalTrials.gov/show/NCT00647699 Completed Avedro, Inc. 2011-04-30
NCT00626717 Riboflavin Mediated Corneal Crosslinking for Stabilizing Progression of Keratoconus https://ClinicalTrials.gov/show/NCT00626717 Completed University Hospital Freiburg 2012-12-31
NCT00593190 Intracameral Gas SF6 (Sulfur Hexafluoride) Injection for Acute Hydrops in Keratoconus https://ClinicalTrials.gov/show/NCT00593190 Completed HaEmek Medical Center, Israel 2008-12-31
NCT00567671 Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia https://ClinicalTrials.gov/show/NCT00567671 Completed Emory University 2010-06-30
NCT00409955 Lamellar Transplant With Lyophilized Corneas https://ClinicalTrials.gov/show/NCT00409955 Completed Federal University of São Paulo NA

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03115710 The K-Map Study, Global Prevalence of KC https://ClinicalTrials.gov/show/NCT03115710 Recruiting University Hospital, Geneva 2021-02-01
NCT03030755 Corneal Elastography and Patient Specific Modeling https://ClinicalTrials.gov/show/NCT03030755 Recruiting The Cleveland Clinic 2020-05-31
NCT02891655 KERatoconus and Metalloproteinases InvesTigation https://ClinicalTrials.gov/show/NCT02891655 Recruiting Fondation Ophtalmologique Adolphe de Rothschild 2020-06-30
NCT02883881 Correlation Between Eye Rubbing and Keratoconus Severity in a Treatment-naive Keratoconic Population https://ClinicalTrials.gov/show/NCT02883881 Completed Centre Hospitalier Régional Metz-Thionville 2015-12-31
NCT02883868 Stromal Demarcation Line: is it Predictive for Cross-Linking Efficiency? https://ClinicalTrials.gov/show/NCT02883868 Completed Centre Hospitalier Régional Metz-Thionville 2015-12-31
NCT02875145 Impact of Cataract Surgery on Keratoplasty Graft Survival https://ClinicalTrials.gov/show/NCT02875145 Completed Centre Hospitalier Universitaire de Besancon 2015-08-31
NCT02812563 Familial Analysis of Keratoconus Risk https://ClinicalTrials.gov/show/NCT02812563 Completed University Hospital, Bordeaux 2017-09-19
NCT02698709 Astigmatic Vector Analysis of Posterior Cornea - a Comparison Among Healthy, Forme Fruste and Overt Keratoconus Corneas https://ClinicalTrials.gov/show/NCT02698709 Completed University of Sao Paulo 2015-08-31
NCT02617368 Fourier Transform of Videokeratography Data: Clinical Usefulness in Moderate and Frome Fruste Keratoconus https://ClinicalTrials.gov/show/NCT02617368 Completed Democritus University of Thrace 2015-11-30
NCT02476149 Biomechanical Properties of Keratoconic Eyes https://ClinicalTrials.gov/show/NCT02476149 Recruiting University of Plymouth 2019-12-31
NCT02428166 Corneal Changes After Crosslinking in Keratoconus Patients Compared to the Untreated Fellow Eye https://ClinicalTrials.gov/show/NCT02428166 Completed Heidelberg University 2017-03-31
NCT02118922 A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia https://ClinicalTrials.gov/show/NCT02118922 Recruiting Massachusetts General Hospital 2020-09-30
NCT02109848 Observational Study of Keratoconus and Post-keratoplasty Eyes https://ClinicalTrials.gov/show/NCT02109848 Completed Oregon Health and Science University 2017-08-31
NCT03355430 Simultaneous Corneal Wavefront-Guided Trans-PRK and Corneal Collagen Crosslinking After ICRS Implantation for Moderate Keratoconus https://ClinicalTrials.gov/show/NCT03355430 Completed Yonsei University 2017-01-02
NCT01879631 Efficacy of Radial Keratotomy in the Optical Rehabilitation of Mild to Moderate Keratoconus Cases https://ClinicalTrials.gov/show/NCT01879631 Completed Nisa Hastanesi 2012-11-30
NCT01726283 Combined CXL//UV and PRK or LASIK in Forme Fruste Keratoconus or Eyes With Potential Risk of Ectasia https://ClinicalTrials.gov/show/NCT01726283 Completed Cxlusa 2014-07-31
NCT01695811 Femtosecond Laser-Assisted Keratoplasty https://ClinicalTrials.gov/show/NCT01695811 Completed University of Michigan 2012-03-31
NCT01654614 Diagnostic Capacity of Keratoconus Match Index and Keratoconus Match Probability in Forme Fruste Keratoconus https://ClinicalTrials.gov/show/NCT01654614 Completed Democritus University of Thrace 2012-06-30
NCT01527708 Accuracy of Curvature and Wavefront Aberrations of Posterior Corneal Surface, in Keratoconic and Post-CXL Corneas https://ClinicalTrials.gov/show/NCT01527708 Completed Democritus University of Thrace 2011-11-30
NCT01510392 CEI Van Outreach Screening Study https://ClinicalTrials.gov/show/NCT01510392 Completed Oregon Health and Science University 2017-02-02
NCT01448408 Corneal Biomechanical Properties and Anterior Segment Parameters, in Forme Fruste Keratoconus https://ClinicalTrials.gov/show/NCT01448408 Completed Democritus University of Thrace NA
NCT01403129 Keratoconus Detection by Ultrasound https://ClinicalTrials.gov/show/NCT01403129 Enrolling by invitation Columbia University 2019-09-30
NCT04433936 Corneal Tomographic Parameters in TGD https://ClinicalTrials.gov/show/NCT04433936 Completed Mansoura University 2018-06-01
NCT04422080 Retrospective Observational Study of Posterior Keratometry Measured https://ClinicalTrials.gov/show/NCT04422080 Completed University Hospital, Montpellier 2020-06-01
NCT04383366 Agreement and Accuracy of Different Devices Corneal Measurements https://ClinicalTrials.gov/show/NCT04383366 Recruiting Medical University of Vienna 2020-10-21
NCT04346992 Prevalence Of Keratoconus Among Patients With Thyroid Gland Dysfunction https://ClinicalTrials.gov/show/NCT04346992 Recruiting Fayoum University 2020-08-31
NCT04313387 Efficiency of an Algorithm Derived From Corneal Tomography Parameters to Distinguish Highly Susceptible Corneas to Ectasia From Healthy https://ClinicalTrials.gov/show/NCT04313387 Completed Sao Jose do Rio Preto Medical School 2018-01-01
NCT04251143 Dresden Corneal Disease and Treatment Study https://ClinicalTrials.gov/show/NCT04251143 Recruiting Technische Universität Dresden 2025-12-31
NCT04249180 Eye Rubbing and Keratoconus in Montpellier CHU https://ClinicalTrials.gov/show/NCT04249180 Recruiting University Hospital, Montpellier 2020-06-01
NCT04180111 Cross Linking Corneal Biomechanical Evaluation of CATS Tonometer Prism https://ClinicalTrials.gov/show/NCT04180111 Recruiting Intuor Technologies, Inc. 2019-12-30
NCT04164407 Keratoconus, Corneal Diseases and Transplant Registry https://ClinicalTrials.gov/show/NCT04164407 Recruiting University Hospital, Montpellier 2021-12-01
NCT03753009 Iontophoretic Transepithelial Collagen Cross-linking Versus Epithelium-off Collagen Cross-linking in Pediatric Patients. Three Year Follow up. https://ClinicalTrials.gov/show/NCT03753009 Completed Bambino Gesù Hospital and Research Institute 2015-06-30
NCT03661164 Iontophoretic Transepithelial Corneal Cross-linking in Pediatric Patients https://ClinicalTrials.gov/show/NCT03661164 Completed Bambino Gesù Hospital and Research Institute 2015-06-30
NCT03637673 The Possible Role of Thyroxine in Keratoconus Development https://ClinicalTrials.gov/show/NCT03637673 Recruiting Alexandria University 2018-08-30
NCT03511495 Reliability of Topography Measurements in Keratoconus https://ClinicalTrials.gov/show/NCT03511495 Completed Milton S. Hershey Medical Center 2019-03-31
NCT03504800 OCT in Diagnosis of Irregular Corneas https://ClinicalTrials.gov/show/NCT03504800 Recruiting Oregon Health and Science University 2023-04-30
NCT03462355 Tobacco Smoking Among Crosslinked-keratoconus Patients https://ClinicalTrials.gov/show/NCT03462355 Completed Centre Hospitalier Régional Metz-Thionville 2017-09-30
NCT01261013 Intrastromal Corneal Ring Segment Implantation in 219 Keratoconic Eyes at Different Stages https://ClinicalTrials.gov/show/NCT01261013 Completed Fernandez-Vega Ophthalmological Institute NA
NCT00863876 Comparison of WaveLight Analyzer and Alcon LadarWave https://ClinicalTrials.gov/show/NCT00863876 Completed WaveLight AG NA
NCT03288116 Objective and Subjective Diagnostic Parameters in the Fellow Eye of Unilateral Keratoconus https://ClinicalTrials.gov/show/NCT03288116 Completed Dar Al Shifa Hospital 2015-02-05
NCT01471873 Variability of Pentacam-derived Back Elevation Measurements in Keratoconus and Cross-linked Corneas https://ClinicalTrials.gov/show/NCT01471873 Completed Democritus University of Thrace 2011-09-30
NCT03184610 Distinguishing Healthy and Keratoconic Eyes Using Ultrahigh-Resolution OCT https://ClinicalTrials.gov/show/NCT03184610 Completed Medical University of Vienna 2017-06-30
NCT02023619 Corneal Epithelial and Stromal Thickness Distribution in Keratoconus https://ClinicalTrials.gov/show/NCT02023619 Completed SynsLaser Kirurgi AS 2013-09-30
NCT04299399 Corneal Biomechanical Changes of Allergic Conjunctivitis https://ClinicalTrials.gov/show/NCT04299399 Recruiting Zhongshan Ophthalmic Center, Sun Yat-sen University 2021-05-31
NCT00584285 Corneal Topographer Fluorescein Patterns https://ClinicalTrials.gov/show/NCT00584285 Completed University of Iowa 2009-09-04
NCT00560651 German Corneal Cross Linking Register https://ClinicalTrials.gov/show/NCT00560651 Recruiting St. Franziskus Hospital 2027-11-30
NCT00347191 Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments. https://ClinicalTrials.gov/show/NCT00347191 Completed Aston University NA
NCT00347074 A Clinical Study of Keratoconus in Asian Patients and Assessment of Different Topographic Patterns of Keratoconus in Asian Patients https://ClinicalTrials.gov/show/NCT00347074 Completed Singapore National Eye Centre NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT02849808 Long Term Cornea Graft Survival Study https://ClinicalTrials.gov/show/NCT02849808 Completed Centre Hospitalier Universitaire de Besancon 2017-08-03
NCT03923101 The Homburg Keratoconus Center (HKC) https://ClinicalTrials.gov/show/NCT03923101 Recruiting Saarland University 2021-01-01